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3FMO,1ERJ,1GXR,1JV2,1K8K,1P22,1PEV,1S4U,1TBG,1VYH,1YFQ,2B4E,2GNQ,2PM9,2VDU,2ZKQ,3ACP,3DW8,3FM0,3GFC,3GRE,3I2N,3JPX
Conserved Protein Domain Family 7WD40
Entrez CDD Structure Protein Help ? sd00039: 7WD40 Download alignment WD40 repeats in seven bladed beta propellers The WD40 repeat is found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing, and cytoskeleton assembly. It typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40. Between the GH and WD dipeptides lies a conserved core. It forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel beta-sheet. The WD40 sequence repeat originally described in literature forms the first three strands of one blade and the last strand in the next blade. The C-terminal WD40 repeat completes the blade structure of the N-terminal WD40 repeat to create the closed ring propeller-structure. The residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands, allowing them to bind either stably or reversibly. Links ? Source: Smart Taxonomy: Opisthokonta PubMed: 5 links Protein: Representatives Specific Protein Related Protein Related Structure Architectures Superfamily: cl37617 Statistics ? PSSM-Id: 293791 Aligned: 23 rows Threshold Bit Score: 73.5357 Threshold Setting Gi: 16975253 Created: 23-Feb-2015 Updated: 6-Nov-2015 Structure ? Program: Cn3D Drawing: All Atoms Virtual Bond Aligned Rows: Download Cn3D Conserved Features/Sites? PubMed References? WD40 repeatWD40 repeatWD40 repeatWD40 repeatWD40 repeat Feature 1:WD40 repeat [structural motif] Evidence: None Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display Sequence Alignment include consensus sequence ? Format:Hypertext Plain Text mFasta Compact Hypertext Compact Text Row Display: Color Bits:0.5 bit 1.0 bit 1.5 bit 2.0 bit 2.5 bit 3.0 bit 3.5 bit 4.0 bit Identity Type Selection:top listed sequences the most diverse members Feature 1 ###### ###### ####### ## ##### 3FMO_A 39 SSLLAVsnk----ygLVFAGGa------------SGLQIFPtknlliqnkpgddpnkivdkvQG-LLVPMkf-------- 93 human1JV2_A 20 GFAVDFfvpsassrmFLLVGApkanttqpgivegGQVLKCDwss----------------trRC-QPIEFdatgnrdyak 82 human1K8K_C 11 ISCHAWnkd----rtQIAICPn-----------nHEVHIYEksg---------------nkwVQvHELKEhng------- 53 cow1PEV_A 21 AVVLGNtpa----gdKIQYCNg------------TSVYTVPvgs----------------ltDT-EIYTEhsh------- 60 nematode1S4U_X 29 IFSVSAcn------sFTVSCSg-----------dGYLKVWDnklldn----------enpkdKS-YSHFVhks------- 73 baker's yeast1YFQ_A 14 ISDIKIips----ksLLLITSw-----------dGSLTVYKfdiq-------------aknvDLlQSLRYkh-------- 57 baker's yeast2B4E_A 37 SGFCAVnp------kFMALICeas--------ggGAFLVLPlgktg------------rvdkNV-PLVCGhta------- 82 house mouse3ACP_A 96 YTAVDTakl---qmrRFILGTt-----------eGDIKVLDsn------------------fNLqREIDQahv------- 136 baker's yeast3DW8_B 31 ISTVEFnhs----geLLATGDk-----------gGRVVIFQqeqenkiq------shsrgeyNVySTFQShepefdylk- 88 Norway rat3GRE_A 66 ITSSAVspg---etpYLITGSd-----------qGVIKIWNlkeii-----------vgevySSsLTYDCss-------- 112 baker's yeast Feature 1 3FMO_A 94 -----------piHHLALScd-------nlTLSACMmsse----------ygsIIAFFdvrtfsn--------------- 130 human1JV2_A 83 ddplefkshqwfgASVRSKq---------dKILACAplyhwrtemkqerepvgTCFLQdg-------------------- 133 human1K8K_C 54 -----------qvTGVDWApd-------snRIVTCGtd--------------rNAYVWtlkg------------------ 83 cow1PEV_A 61 -----------qtTVAKTSps-------gyYCASGDvh--------------gNVRIWdttq------------------ 90 nematode1S4U_X 74 -----------glHHVDVLqaierdafelcLVATTSfs--------------gDLLFYritrede--------------- 113 baker's yeast1YFQ_A 58 -----------plLCCNFIdnt------dlQIYVGTvq--------------gEILKVdli------------------- 87 baker's yeast2B4E_A 83 -----------pvLDIAWCphn------dnVIASGSed--------------cTVMVWeipdggl--------------- 116 house mouse3ACP_A 137 ----------seiTKLKFFps-------geALISSSqd--------------mQLKIWsvk------------------- 166 baker's yeast3DW8_B 89 -----sleieekiNKIRWLpqkn----aaqFLLSTNd---------------kTIKLWkiserdkrpegynlkeedgryr 144 Norway rat3GRE_A 113 -----------tvTQITMIpn-------fdAFAVSSkd--------------gQIIVLkvnhyqqes------------- 147 baker's yeast Feature 1 3FMO_A 131 ----------------eakqqkrPFAYHKLlkda---------ggmVIDMKWNptv----psMVAVCLad-----gSIAV 176 human1JV2_A 134 ----------------------tKTVEYAPcrsqdidadgqgfcqgGFSIDFTka------dRVLLGGpgsfywqgQLIS 185 human1K8K_C 84 --------------------rtwKPTLVILrin-----------raARCVRWApn-----ekKFAVGSgs-----rVISI 122 cow1PEV_A 91 -------------------tthiLKTTIPVfs------------gpVKDISWDse-----skRIAAVGegr---erFGHV 131 nematode1S4U_X 114 -----------------tkkvifEKLDLLDsdmk---------khsFWALKWGasndrllshRLVATDvk-----gTTYI 162 baker's yeast1YFQ_A 88 --------------------gspSFQALTNnea----------nlgICRICKYgd------dKLIAASwd-----gLIEV 126 baker's yeast2B4E_A 117 -----------------vlplrePVITLEGht------------krVGIVAWHpta----qnVLLSAGcd-----nVILV 158 house mouse3ACP_A 167 --------------------dgsNPRTLIGhr------------atVTDIAIIdr-----grNVLSASld-----gTIRL 204 baker's yeast3DW8_B 145 dpttvttlrvpvfrpmdlmveasPRRIFANaht-----------yhINSISINsd-----yeTYLSADd------lRINL 202 Norway rat3GRE_A 148 ---------------evkflnceCIRKINLknfg--------kneyAVRMRAFvne---eksLLVALTnl-----sRVII 196 baker's yeast Feature 1 3FMO_A 177 LQVtet--------------vkvCAT-LPst--------vaVTSVCWSpk---------------------gkQLAVGKq 212 human1JV2_A 186 DQVaeivskydp--nvysikynnQLA-TRtaqaif-ddsylGYSVAVGdfng-----------------dgidDFVSGVp 244 human1K8K_C 123 CYFeqen------------dwwvCKH-IKkpi------rstVLSLDWHpn---------------------svLLAAGSc 162 cow1PEV_A 132 FLFdtg---------------tsNGN-LTgqa-------raMNSVDFKpsr--------------------pfRIISGSd 168 nematode1S4U_X 163 WKFhpfadesnsltlnwsptlelQGT-VEspmt----psqfATSVDISer----------------------gLIATGFn 215 baker's yeast1YFQ_A 127 IDPrnyg-------------dgvIAV-KNlnsnnt-kvknkIFTMDTNs-----------------------sRLIVGMn 168 baker's yeast2B4E_A 159 WDVgtg---------------aaVLT-LGpdvh-----pdtIYSVDWSrd---------------------gaLICTSCr 196 house mouse3ACP_A 205 WECgtg---------------ttIHT-FNrken----phdgVNSIALFvgtdrqlheistskknnlefgtygkYVIAGHv 264 baker's yeast3DW8_B 203 WHLeit---------------drSFNiVDikpanmeeltevITAAEFHpns--------------------cnTFVYSSs 247 Norway rat3GRE_A 197 FDIrtl---------------erLQI-IEnspr-----hgaVSSICIDee---------------------ccVLILGTt 234 baker's yeast Feature 1 3FMO_A 213 n-----gTVVQYLPt-------------------lQEkKVIPcppfye-----sdhpvrVLDVLWIgt-----yVFAIVY 258 human1JV2_A 245 raartlgMVYIYDGkn------------------mSSlYNFTgeqm---------aayfGFSVAATdingddyaDVFIGA 297 human1K8K_C 163 d-----fKCRIFSAyikeveerpaptpwgskmpfgELmFESSssc------------gwVHGVCFSan----gsRVAWVS 221 cow1PEV_A 169 d-----nTVAIFEGpp------------------fKFkSTFGeht------------kfVHSVRYNpd----gsLFASTG 209 nematode1S4U_X 216 n-----gTVQISELst------------------lRPlYNFEsqhsmi------nnsnsIRSVKFSpq----gsLLAIAH 262 baker's yeast1YFQ_A 169 n-----sQVQWFRLplc---------------eddNG-TIEEsgl-----------kyqIRDVALLpke---qeGYACSS 213 baker's yeast2B4E_A 197 d-----kRVRVIEPrk------------------gTVvAEKDrphe----------gtrPVHAVFVse-----gKILTTG 238 house mouse3ACP_A 265 s-----gVITVHNVfs------------------kEQtIQLPskf-----------tcsCNSLTVDgnn---anYIYAGY 307 baker's yeast3DW8_B 248 k-----gTIRLCDMrasa-------------lcdrHS-KLFEepedpsnrsffseiissISDVKFShs----grYMMTRD 304 Norway rat3GRE_A 235 r-----gIIDIWDIrf------------------nVLiRSWSfgd-----------hapITHVEVCqfy--gknSVIVVG 278 baker's yeast Feature 1 3FMO_A 259 aaadgt-----letspDVVMALLpkkee-khpeIF-VNFMepcygs-------------------cterqhHYYLSYIee 312 human1JV2_A 298 plfmdrgsdgklqevgQVSVSLQras----gdfQT-TKLNgfev-----------------------farfGSAIAPLgd 349 human1K8K_C 222 hd-------------sTVCLADAdk------kmAV-ATLAset--------------------------lpLLAVTFIte 255 cow1PEV_A 210 gd-------------gTIVLYNGvd-------gTKtGVFEddslkn-------------------vahsgsVFGLTWSpd 250 nematode1S4U_X 263 dsn----------sfgCITLYETef-------gERiGSLSvpthssqas-------------lgefahsswVMSLSFNds 312 baker's yeast1YFQ_A 214 id-------------gRVAVEFFddqgddynssKR-FAFRchrlnlk-----------------dtnlaypVNSIEFSpr 262 baker's yeast2B4E_A 239 fsrm---------serQVALWDTkh------leEPlSLQEldt-------------------------ssgVLLPFFDpd 278 house mouse3ACP_A 308 en-------------gMLAQWDLrs------peCPvGEFLine-------------------------gtpINNVYFAa- 342 baker's yeast3DW8_B 305 y--------------lSVKVWDLnm------enRPvETYQvheylrsklc-----------slyendcifdKFECCWNgs 353 Norway rat3GRE_A 279 gss-----------ktFLTIWNFvk-------gHCqYAFInsdeqpsmehflpiekgleelnfcgirslnaLSTISVSn- 339 baker's yeast Feature 1 3FMO_A 313 -----wdLVLAASaa-----stEVSILARqsdqinwe-swlledsSRAElpvtdk------------------------- 356 human1JV2_A 350 ldqdgfnDIAIAApyggedkkgIVYIFNGrstgl------navpsQILEgqwaar------------------------- 398 human1K8K_C 256 ------sSLVAAGhd------cFPVLFTYdsaag------klsfgGRLDvpkqssqrgltarerfqnldkkassegsaaa 317 cow1PEV_A 251 -----gtKIASASad------kTIKIWNVatl----------kveKTIPvgtr--------------------------- 282 nematode1S4U_X 313 -----geTLCSAGwd------gKLRFWDVktk----------eriTTLNmhcddieieedil----------------av 355 baker's yeast1YFQ_A 263 -----hkFLYTAGsd------gIISCWNLqtr----------kkiKNFAkfn---------------------------- 293 baker's yeast2B4E_A 279 -----tnIVYLCGkg-----dsSIRYFEItseap------flhylSMFSsk----------------------------- 313 house mouse3ACP_A 343 ------gALFVSSgf------dTSIKLDIisdpeserpaiefetpTFLVsnd---------------------------- 382 baker's yeast3DW8_B 354 -----dsVVMTGSyn------nFFRMFDRntk-----------rdITLEasrennkprtvlkprkvca----sgkrkkde 407 Norway rat3GRE_A 340 ------dKILLTDea-----tsSIVMFSLnel----------sssKAVIspsrfsdvfiptqvtanltmllrkmkrtsth 398 baker's yeast Feature 1 3FMO_A 357 ------sddslPMGVVVdytnqveitisdektlppaPVLMLlst-----------------dgVLCPF 401 human1JV2_A 399 -----smppsfGYSMKGatdid----------kngyPDLIVgaf----------------gvdRAILY 435 human1K8K_C 318 gagldslhknsVSQISVlsgg-----------kakcSQFCTtgm-----------------dgGMSIW 357 cow1PEV_A 283 -------iedqQLGIIWt-----------------kQALVSisa-----------------ngFINFV 309 nematode1S4U_X 356 dehgdslaepgVFDVKFlkkgwrs-----gmgadlnESLCCvcl-----------------drSIRWF 401 baker's yeast1YFQ_A 294 --------edsVVKIACs-----------------dNILCLatsddtfktnaaidqtielnasSIYII 336 baker's yeast2B4E_A 314 ---------esQRGMGYmpkrgle------vnkceiARFYKlh------------------erKCEPI 348 house mouse3ACP_A 383 ---------deVSQFCYvsdd------------esnGEVLEvgk-----------------nnFCALY 412 baker's yeast3DW8_B 408 isvdsldfnkkILHTAWhp---------------keNIIAVat------------------tnNLYIF 442 Norway rat3GRE_A 399 svddslyhhdiINSISTcev-------------detPLLVAcdn-----------------sgLIGIF 436 baker's yeast Citing CDD Lu S et al.(2020). "CDD/SPARCLE: the conserved domain database in 2020.", Nucleic Acids Res. 48(D1):D265-D268. | Disclaimer | Privacy statement | Accessibility |
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